N3-TFBA-O2Oc

CAT: 0804-HY-151744Size: 1 EachDry Ice: NoHazardous: No

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Description

N3-TFBA-O2Oc is a click chemistry reagent containing an azide group and an aryl group. Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors. This type of compounds has been used as photo-cross linker (λmax=258 nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers[1][2][3]. N3-TFBA-O2Oc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

CAS Number

1993119-45-1

UNSPSC

12352005

Hazard Statement

H228

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n3-tfba-o2oc.html

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NC1=C(C(F)=C(C(F)=C1F)C(NCCOCCOCC(O)=O)=O)F

Molecular Formula

C13H12F4N4O5

Molecular Weight

380.25

Precautions

H228

References & Citations

[1]Morris JL, et al. Aryl azide photochemistry in defined protein environments. Org Lett. 2013 Feb 15;15 (4) :728-31. |[2]FLEET G, et al. Affinity Labelling of Antibodies with Aryl Nitrene as Reactive Group. Nature. 1969;224:511-512. |[3]Welle, et al. Tri- and tetravalent photoactivable cross-linking agents. Thieme. 2012;44 (14) :2249-2254.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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