N3-TFBA-O2Oc

N3-TFBA-O2Oc

• CAS Number: 1993119-45-1
• UNSPSC Description: N3-TFBA-O2Oc is a click chemistry reagent containing an azide group and an aryl group. Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors. This type of compounds has been used as photo-cross linker (λmax=258 nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers[1][2][3]. N3-TFBA-O2Oc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: ADC Linker
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/n3-tfba-o2oc.html
• Solubility: 10 mM in DMSO
• Smiles: [N-]=[N+]=NC1=C(C(F)=C(C(F)=C1F)C(NCCOCCOCC(O)=O)=O)F
• Molecular Weight: 380.25
• References & Citations: [1]Morris JL, et al. Aryl azide photochemistry in defined protein environments. Org Lett. 2013 Feb 15;15(4):728-31. |[2]FLEET G, et al. Affinity Labelling of Antibodies with Aryl Nitrene as Reactive Group. Nature. 1969;224:511-512. |[3]Welle, et al. Tri- and tetravalent photoactivable cross-linking agents. Thieme. 2012;44(14):2249-2254.
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported