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N3-L-Cit-OH

CAT: 0804-HY-151709Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151709Size:1 Each
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Description
N3-L-Cit-OH is a click chemistry reagent containing an azide group. N3-L-Cit-OH can be used to construct peptidomimetic ADC linkers using Click-chemistry[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
CAS Number
1799421-66-1
UNSPSC
12352211
Target
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/n3-l-cit-oh.html
Solubility
10 mM in DMSO
Smiles
NC(NCCC[C@@H](C(O)=O)N=[N+]=[N-])=O
Molecular Formula
C6H11N5O3
Molecular Weight
201.18
References & Citations
[1]Eigenbrot C, et al. Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. J Med Chem. 2018 Feb 8;61 (3) :989-1000.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N3-L-Cit-OH
CAS Number1799421-66-1
PubChem CID118183251
IUPAC Name(2S)-2-azido-5-(carbamoylamino)pentanoic acid
Molecular FormulaC6H11N5O3
Molecular Weight201.18
XLogP0.4
Topological Polar Surface Area107
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count14
Formal Charge0
Complexity260
SMILES
C(C[C@@H](C(=O)O)N=[N+]=[N-])CNC(=O)N
InChI
InChI=1S/C6H11N5O3/c7-6(14)9-3-1-2-4(5(12)13)10-11-8/h4H,1-3H2,(H,12,13)(H3,7,9,14)/t4-/m0/s1
InChIKey
WTCIIDRGWZAPDA-BYPYZUCNSA-N
Chemical Structure
2D Structure
2D structure of N3-L-Cit-OH
CAS: 1799421-66-1
CID: 118183251
Formula: C6H11N5O3
MW: 201.18
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight201.18
XLogP30.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass201.08618923
Monoisotopic Mass201.08618923
Topological Polar Surface Area107 Ų
Heavy Atom Count14
Formal Charge0
Complexity260
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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