Fmoc-DAP-N3

• Description:

  Fmoc-DAP-N3 is a click chemistry reagent containing an azide group. Fmoc-DAP-N3 is a short, linear spacer molecule with Fmoc protected amino function. Fmoc-DAP-N3 can be used in click conjugation and amid bond formation either with small molecules or for bioconjugation with proteins and antibodies[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

• UNSPSC:

  12352005

• Target:

  ADC Linker

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/fmoc-dap-n3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (OCC1C2=C (C3=C1C=CC=C3) C=CC=C2) NCCCN=[N+]=[N-]

• Molecular Formula:

  C18H18N4O2

• Molecular Weight:

  322.36

• References & Citations:

  [1] Chun-Chi Chen, et al. A mild removal of Fmoc group using sodium azide. Amino Acids. 2014 Feb;46 (2) :367-74.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1021422-85-4