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MAGLi 432

CAT: 0804-HY-150702Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150702Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAGLi 432 is a non-covalent, potent, highly selective, and reversible MAGL inhibitor. MAGLi 432 binds with high affinity to the MAGL active site, with IC50 values of 4.2 nM (human enzyme) and 3.1 nM (mouse enzyme) . MAGLi 432 can be used in the research of chronic inflammation, blood–brain barrier dysfunction, neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease[1].
CAS Number
2361575-20-2
UNSPSC
12352005
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/magli-432.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(OC)=C1Br)N2C[C@](CC[C@H](C3=CC=C(Cl)C=C3)C4)([H])N4CC2
Molecular Formula
C22H24BrClN2O2
Molecular Weight
463.80
References & Citations
[1]Alicia Kemble, et al. A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature. bioRxiv 2022.05.04.490688.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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