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TXA6101

CAT: 0804-HY-150699Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150699Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections[1][2].
CAS Number
1459695-66-9
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/txa6101.html
Solubility
10 mM in DMSO
Smiles
O=C(N)C1=C(F)C=CC(OCC2=NC(C3=CC=C(C(F)(F)F)C=C3)=C(Br)O2)=C1F
Molecular Formula
C18H10BrF5N2O3
Molecular Weight
477.18
References & Citations
[1]Andrea Casiraghi, et al. Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ. Antibiotics (Basel) . 2020 Feb 7;9 (2) :69.|[2]Junso Fujita, et al. Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ. ACS Chem Biol. 2017 Jul 21;12 (7) :1947-1955.|[3]Jesus D Rosado-Lugo, et al. Evaluation of 2,6-difluoro-3- (oxazol-2-ylmethoxy) benzamide chemotypes as Gram-negative FtsZ inhibitors. J Antibiot (Tokyo) . 2022 Jul;75 (7) :385-395.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
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