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Butabindide

CAT: 0804-HY-150070Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150070Size:1 Each
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Description
Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation[1][2].
CAS Number
175553-48-7
Product Name Alternative
UCL-1397
UNSPSC
12352005
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/butabindide.html
Solubility
10 mM in DMSO
Smiles
CC[C@H](N)C(N1C2=CC=CC=C2C[C@H]1C(NCCCC)=O)=O
Molecular Formula
C17H25N3O2
Molecular Weight
303.40
References & Citations
[1]Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48 (23) :7333-42.|[2]Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380 (6573) :403-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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