Butabindide

Butabindide

• CAS Number: 175553-48-7
• UNSPSC Description: Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation[1][2].
• Target Antigen: Ser/Thr Protease
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/butabindide.html
• Solubility: 10 mM in DMSO
• Smiles: CC[C@H](N)C(N1C2=CC=CC=C2C[C@H]1C(NCCCC)=O)=O
• Molecular Weight: 303.40
• References & Citations: [1]Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48(23):7333-42.|[2]Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380(6573):403-9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported