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TP0480066

CAT: 0804-HY-150045Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150045Size:1 Each
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Description
TP0480066 is a selective topoisomerase II inhibitor with IC50s of 1.10 and 62.89 nM for DNA gyrase and topo IV, respectively. TP0480066 shows good activity of againsting various bacterial species including drug-resistant strains. TP0480066 also exhibits potent inhibitory activity to N. gonorrhoeae, can be used in study of gonorrhea[1][2].
CAS Number
2245693-15-4
UNSPSC
12352005
Target
Bacterial; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tp0480066.html
Solubility
10 mM in DMSO
Smiles
CNC1=CC(F)=CC2=C1NC(C(C(NC3=CC=C(C=C3)C(O)=O)=O)=C2O)=O
Molecular Formula
C18H14FN3O5
Molecular Weight
371.32
References & Citations
[1]Ushiyama F, et al. Lead optimization of 8- (methylamino) -2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. Bioorg Med Chem. 2020 Nov 15;28 (22) :115776.|[2]Masuko A, et al. In Vitro and In Vivo Activities of TP0480066, a Novel Topoisomerase Inhibitor, against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2021 Mar 18;65 (4) :e02145-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II

Alternative Products

CatalogName
T61481-01TP0480066

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