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Anthramycin

CAT: 0804-HY-150036Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150036Size:1 Each
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Description
Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice[1][2][3].
CAS Number
4803-27-4
UNSPSC
12352005
Target
Antibiotic; Cholecystokinin Receptor
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anthramycin.html
Solubility
10 mM in DMSO
Smiles
O=C1N2[C@@]([C@H](NC3=C(O)C(C)=CC=C31)O)([H])CC(/C=C/C(N)=O)=C2
Molecular Formula
C16H17N3O4
Molecular Weight
315.32
References & Citations
[1]Haque T, et al. Topical delivery of anthramycin II. Influence of binary and ternary solvent systems. Eur J Pharm Sci. 2018 Aug 30;121:59-64.|[2]Kubota K, et al. Cholecystokinin antagonism by anthramycin, a benzodiazepine antibiotic, in the central nervous system in mice. Brain Res. 1989 Apr 17;485 (1) :62-6. |[3]Cargill C, et al. Effects of daunomycin and anthramycin on electrocardiogram and mitochondrial metabolism of the rat heart. J Natl Cancer Inst. 1974 Aug;53 (2) :481-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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