SIMR3030

CAT: 0804-HY-149940Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-149940Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice[1].

CAS Number

2708270-99-7

UNSPSC

12352005

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/simr3030.html

Solubility

10 mM in DMSO

Smiles

[H][C@@]12CC[C@]3(CC4=C(NC5=C4C=C(C=C5)OC)C[C@]3(N1CCC6=C2NC7=CC=CC=C76)[H])OC

Molecular Formula

C27H29N3O2

Molecular Weight

427.54

References & Citations

[1]Hersi F, et al. Discovery of novel papain-like protease inhibitors for potential treatment of COVID-19. Eur J Med Chem. 2023 Jun 5;254:115380.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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