BMV109

CAT: 0804-HY-149931Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-149931Size:1 Each

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Description

BMV109 is a quenched probe that becomes fluorescent when cleaved and covalently bound by active cathepsin proteases. BMV109 can be exploited for tumor imaging[1][2].

CAS Number

1458731-58-2

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bmv109.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=C(C=CC=C1)C(C2=CC=C(N3C4=CC=C(S(=O)([O-])=O)C=C4CC3)C=C2O5)=C(C=C/6)C5=CC6=[N+]7C8=CC=C(S(=O)(O)=O)C=C8CC/7)(N9CCC(CC9)C(NCCNC(C%10=C(C(F)=C(C(F)=C%10F)OCC([C@H](CCCCNC(CCCCCN%11C%12=CC=C(S(=O)(O)=O)C=C%12C(C)(/C%11=C/C=C/C=C/C%13=[N+](C%14=CC=C(S(=O)([O-])=O)C=C%14C%13(C)C)CC)C)=O)NC([C@@H](NC(OCC%15=CC=CC=C%15)=O)CC%16=CC=CC=C%16)=O)=O)F)=O)=O)=O

Molecular Formula

C107H108F4N10O23S5

Molecular Weight

2138.37

References & Citations

[1]Martijn Verdoes, et al. Improved quenched fluorescent probe for imaging of cysteine cathepsin activity. J Am Chem Soc. 2013 Oct 2;135 (39) :14726-30. |[2]Steven Sensarn, et al. A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer. Mol Imaging Biol. 2016 Dec;18 (6) :820-829.

Shipping Conditions

Room temperature

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

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