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JH530

CAT: 0804-HY-149847Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149847Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JH530 is an effective methuosis inducer that inhibits the triple-negative breast cancer (TNBC) cells proliferation by causing intracellular complete vacuolization. JH530 has anti-tumor activity and can be used for cancer research[1].
CAS Number
2928616-74-2
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jh530.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(Br)=N1)NC2=C(OC)C=C(NC3=NC(N4CCNCC4)=NC=C3SC)C=C2
Molecular Formula
C22H24BrN7O2S
Molecular Weight
530.44
References & Citations
[1]He J, et al. Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jun 8;66 (11) :7421-7437.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T86768-01JH530

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