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AcrB-IN-3

CAT: 0804-HY-149811Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149811Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Efflux pump-IN-3 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-3 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-3 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model[1].
CAS Number
2890177-94-1
UNSPSC
12352005
Target
Bacterial; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/acrb-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(OCCCOC2=CC=CC3=C2C=C(C(N4CCOCC4)=O)C5=C3OC(C)(CC5)C)=CC=C1)O
Molecular Formula
C30H33NO7
Molecular Weight
519.59
References & Citations
[1]Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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