Phosphodiesterase-IN-1

• UNSPSC Description:

  Phosphodiesterase-IN-1 (Compound 7) is a phosphodiesterase (PDE) inhibitor with anti-Plasmodium activity. Phosphodiesterase-IN-1 has antiproliferative activity against P. falciparum (strain 3D7) with an IC50 value of 0.64 μM[1].

• Target Antigen:

  Parasite; Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/phosphodiesterase-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N=C(CC2=CC=C(C=C2)F)NC3=C1NN=C3C(C)C

• Molecular Weight:

  286.30

• References & Citations:

  [1]Howard BL, et al. Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites. ACS Chem Biol. 2015 Apr 17;10(4):1145-54.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  521297-42-7