Laccase-IN-1

• UNSPSC Description:

  Laccase-IN-1 (compound 4b) is an orally active inhibitor of laccase, with the IC50 of 11.3 μM. Laccase-IN-1displays protective and curative effects on apple fruits infected by B. dothidea. Laccase-IN-1 enhances the cell membrane permeability, destroys the mycelial surface morphology and the cell ultrastructure, and reduces the ergosterol and exopolysaccharide contents of B. dothidea[1].

• Target Antigen:

  Endogenous Metabolite; Fungal

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/laccase-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC(C=C1)=CC=C1NNC([C@@]2(CC[C@@]3(C2(C)C)C)OC3=O)=O

• Molecular Weight:

  306.33

• References & Citations:

  [1]Yang Z, et al. Design, Synthesis, and Biological Evaluation of Novel Camphor-Based Hydrazide and Sulfonamide Derivatives as Laccase Inhibitors against Plant Pathogenic Fungi/Oomycetes. J Agric Food Chem. 2023;71(39):14151-14163.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2991094-41-6