Human Insulin-like Growth Factor-Binding Protein 5

• Description:

  Human Insulin-like Growth Factor-Binding Protein 5_x000D_ Catalog number: B2010281_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Volume/Weight: 10 ug_x000D_ pH: 7.4 upon reconstitution_x000D_ Supplied as: Lyophilized Powder_x000D_ Appearance: Powder_x000D_ Applications: highly pure Human Insulin-like Growth Factor-Binding Protein 5 (Human) expressed in CHO cells. This protein acts as a peculiar protein that modulates the action of secreted insulin-like growth factors. It also stimulates osteoblast proliferation._x000D_ Storage: -20C_x000D_ Keywords: rHuIGF-BP5; IBP-5_x000D_ Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Capuano AW, Wilson RS, Honer WG, Petyuk VA, Leurgans SE, Yu L, Gatchel JR,_x000D_ Arnold S, Bennett DA, Arvanitakis Z. Brain IGFBP-5 modifies the relation of_x000D_ depressive symptoms to decline in cognition in older persons. J Affect Disord._x000D_ 2019 May 1;250:313-318._x000D_ _x000D_ 2: Hwang JR, Cho YJ, Lee Y, Park Y, Han HD, Ahn HJ, Lee JH, Lee JW. The_x000D_ C-terminus of IGFBP-5 suppresses tumor growth by inhibiting angiogenesis. Sci_x000D_ Rep. 2016 Dec 23;6:39334._x000D_ _x000D_ 3: Su Y, Nishimoto T, Feghali-Bostwick C. IGFBP-5 Promotes Fibrosis_x000D_ Independently of Its Translocation to the Nucleus and Its Interaction with_x000D_ Nucleolin and IGF. PLoS One. 2015 Jun 23;10(6):e0130546._x000D_ _x000D_ 4: Flint DJ, Beattie J, Allan GJ. Modulation of the actions of IGFs by IGFBP-5_x000D_ in the mammary gland. Horm Metab Res. 2003 Nov-Dec;35(11-12):809-15._x000D_ _x000D_ 5: DiPrisco B, Kumar A, Kalra B, Savjani GV, Michael Z, Farr O, Papathanasiou_x000D_ AE, Christou H, Mantzoros C. Placental proteases PAPP-A and PAPP-A2, the binding_x000D_ proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: Levels in umbilical_x000D_ cord blood and associations with birth weight and length. Metabolism. 2019_x000D_ Nov;100:153959._x000D_ _x000D_ 6: Mohan S, Farley JR, Baylink DJ. Age-related changes in IGFBP-4 and IGFBP-5_x000D_ levels in human serum and bone: implications for bone loss with aging. Prog_x000D_ Growth Factor Res. 1995;6(2-4):465-73._x000D_ _x000D_ 7: Pan J, Li K, Huang W, Zhang X. MiR-137 inhibited cell proliferation and_x000D_ migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating_x000D_ the mTOR/STAT3 signaling. PLoS One. 2017 Oct 10;12(10):e0186245._x000D_ _x000D_ 8: Mohan S, Baylink DJ. Serum insulin-like growth factor binding protein_x000D_ (IGFBP)-4 and IGFBP-5 levels in aging and age-associated diseases. Endocrine._x000D_ 1997 Aug;7(1):87-91._x000D_ _x000D_ 9: Allan GJ, Beattie J, Flint DJ. The role of IGFBP-5 in mammary gland_x000D_ development and involution. Domest Anim Endocrinol. 2004 Oct;27(3):257-66._x000D_ 10: Tonner E, Allan G, Shkreta L, Webster J, Whitelaw CB, Flint DJ. Insulin-like_x000D_ growth factor binding protein-5 (IGFBP-5) potentially regulates programmed cell_x000D_ death and plasminogen activation in the mammary gland. Adv Exp Med Biol._x000D_ 2000;480:45-53. _x000D_ _x000D_ Products Related to Human Insulin-like Growth Factor-Binding Protein 5 (Human) : Proteins

• Short Description:

  Catalog Number: B2010281 (10 ug)_x000D_ Human Insulin-like Growth Factor-Binding Protein 5 (Human) is a high quality research product used as highly pure Human Insulin-like Growth Factor-Binding Protein 5 (Human) expressed in CHO cells. This protein acts as a peculiar protein that modulates the action of secreted insulin-like growth factors. It also stimulates osteoblast proliferation. Custom bulk orders of this product are available upon request.

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5