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Vem-L-Cy5

CAT: 0804-HY-149380-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149380-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vem-L-Cy5 (compound 3), modified with the NIR fluorophore cyanine-5 (Cy5), is a Vemurafenib -based inhibitor of BRAF. Vem-L-Cy5 targets to BRAFV600E, and also inhibits MEK phosphorylation. Vem-L-Cy5 has cell permeability, and inhibits cell growth of many types of cancer[1].
CAS Number
3057544-65-4
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vem-l-cy5.html
Purity
98.31
Solubility
DMSO : 50 mg/mL
Smiles
CC1(C)C(/C=C/C=C/C=C2N(CCCCCC(NCCOCCOCC(NC3=CC=C(C4=CN=C(NC=C5C(C6=C(F)C=CC(NS(=O)(CCC)=O)=C6F)=O)C5=C4)C=C3)=O)=O)C7=C(C=CC=C7)C/2(C)C)=[N+](C)C8=C1C=CC=C8.O=C([O-])C(F)(F)F
Molecular Formula
C63H68F5N7O9S
Molecular Weight
1194.31
References & Citations
[1]Barresi E, et al. A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells. Eur J Med Chem. 2023 Aug 5;256:115446.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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