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DG1

CAT: 0804-HY-149352Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149352Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DG1 (Compound 8Nc) is a Thymidylate Synthase (TS) inhibitor that affects cancer angiogenesis and metabolic reprogramming in NSCLC cells. DG1 can effectively inhibit the expression of CD26, ET-1, FGF-1 and EGF. DG1 also effectively inhibits the proliferation of cancer tissue in the A549 xenograft mouse model[1].
UNSPSC
12352005
Target
Thymidylate Synthase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dg1.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(NC=C1S(=O)(NC2=CC=CC(C(N/N=C/C3=CC(C)=CC=C3)=O)=C2)=O)=O
Molecular Formula
C19H17N5O5S
Molecular Weight
427.43
References & Citations
[1]Dong G, et al. Discovery of novel thymidylate synthase (TS) inhibitors that influence cancer angiogenesis and metabolic reprogramming in NSCLC cells. Eur J Med Chem. 2023 Oct 5;258:115600.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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