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DiPT-4

CAT: 0804-HY-149348Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149348Size:1 Each
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Description
DiPT-4 is a dual TOP1/PARP1 inhibitor that induces massive DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells. DiPT-4 has the potential to overcome cancer drug resistance[1].
CAS Number
3052259-89-6
UNSPSC
12352005
Target
Apoptosis; PARP; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dipt-4.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CC2=NN=C(SCCN3C(C4=CC=CC5=CC=CC(C3=O)=C45)=O)O2)N=C(CC6=CC=C(F)C=C6)C7=C1C=CC=C7
Molecular Formula
C32H22FN5O4S
Molecular Weight
591.61
References & Citations
[1]Guha Majumdar A, et al. Design, synthesis and development of a dual inhibitor of Topoisomerase 1 and poly (ADP-ribose) polymerase 1 for efficient killing of cancer cells. Eur J Med Chem. 2023 Oct 5;258:115598.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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