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Naproxcinod

CAT: 0804-HY-14931Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14931Size:1 Each
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Description
Naproxcinod (Nitronaproxen) is the first in class of cyclooxygenase (COX) -inhibiting nitric oxide donators (CINODs) . Naproxcinod shows analgesic and anti-inflammatory effects, it can be used for the research of osteoarthritis and inflammation[1][2][3].
CAS Number
163133-43-5
Product Name Alternative
AZD 3582; HCT 3012; Nitronaproxen
UNSPSC
12352005
Hazard Statement
H302-H373-H400-H410
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/naproxcinod.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C1=CC=C2C=C(OC)C=CC2=C1)C(OCCCCO[N+]([O-])=O)=O
Molecular Formula
C18H21NO6
Molecular Weight
347.36
Precautions
P260-P264-P270-P273-P330-P391-P501
References & Citations
[1]Berndt G, et al. A common pathway of nitric oxide release from AZD3582 and glyceryl trinitrate. Eur J Pharm Sci. 2004 Feb;21 (2-3) :331-5.|[2]Berndt G, et al. AZD3582 increases heme oxygenase-1 expression and antioxidant activity in vascular endothelial and gastric mucosal cells. Eur J Pharm Sci. 2005 Jun;25 (2-3) :229-35. |[3]Uaesoontrachoon K, et al. Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in the mdx mouse model of dystrophy. Hum Mol Genet. 2014 Jun 15;23 (12) :3239-49.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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