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H1k

CAT: 0804-HY-149261Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149261Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H1k, a Eudistomin Y derivative, is a lysosome-targeted antiproliferation agent. H1k increases the autophagy signal and downregulate the expression of cyclin-dependent kinase (CDK1) and cyclin B1. H1k can be used in research of cancer[1].
UNSPSC
12352005
Target
Autophagy; CDK
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/h1k.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)CN2C3=C(C4=C2C(C(C5=CC=CC=C5)=O)=NC=C4)C=CC=C3
Molecular Formula
C26H20N2O2
Molecular Weight
392.45
References & Citations
[1]Yang G, et, al. Design, synthesis, and discovery of Eudistomin Y derivatives as lysosome-targeted antiproliferation agents. Eur J Med Chem. 2023 Mar 15;250:115193.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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