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CXJ-2

CAT: 0804-HY-149205Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149205Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs) . CXJ-2 exhibits potent activities to inhibit the PI3K/ERK pathway and decrease hepatic stellate cell proliferation and migration. CXJ-2 possesses potent antifibrotic efficacy[1].
CAS Number
2919976-92-2
UNSPSC
12352209
Target
ERK; PI3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cxj-2.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC1=O)C(C)C)N[C@](CC)(C(NCC(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H]1C)=O)CCC3)=O)CO)=O)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(N)=O)=O)C)=O)CO)=O)CCC2)=O)CO)=O)=O)C
Molecular Formula
C55H87N15O22
Molecular Weight
1310.37
References & Citations
[1]Song N, et al. Design and Discovery of Novel Cyclic Peptides as EDPs-EBP Interaction Inhibitors for the Treatment of Liver Fibrosis. J Med Chem. 2023 Apr 13;66 (7) :4689-4702.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK; PI3K

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