Azilsartan-d4

• Description :

  Azilsartan-d4 is the deuterium labeled Azilsartan[1]. Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research[2][3][4][5][6].

• Product Name Alternative :

  TAK-536-d4

• UNSPSC :

  12352005

• Target :

  Angiotensin Receptor; Apoptosis; Reactive Oxygen Species (ROS)

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer

• Solubility :

  10 mM in DMSO

• Smiles :

  CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC3=C([2H])C([2H])=C(C4=C(C5=NOC(N5)=O)C=CC=C4)C([2H])=C3[2H]

• Molecular Formula :

  C25H16D4N4O5

• Molecular Weight :

  460.47

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kajiya T, et al. Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J Hypertens. 2011 Dec;29 (12) :2476-83.|[3]Zhao M, et al. Azilsartan treatment improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats. Diabetes Obes Metab. 2011 Dec;13 (12) :1123-9.|[4]Ojima M, et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther. 2011 Mar;336 (3) :801-8.|[5]Gupta V, et al. Neuroprotective potential of azilsartan against cerebral ischemic injury: Possible involvement of mitochondrial mechanisms. Neurochem Int. 2020 Jan;132:104604.|[6]Ahmadian E, et al. Novel angiotensin receptor blocker, azilsartan induces oxidative stress and NFkB-mediated apoptosis in hepatocellular carcinoma cell line HepG2. Biomed Pharmacother. 2018 Mar;99:939-946.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1794817-45-0]