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MR2938

CAT: 0804-HY-149087-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149087-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM) . MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research[1].
CAS Number
1044870-65-6
UNSPSC
12352005
Target
CCR; Cholinesterase (ChE) ; Interleukin Related; JNK; NF-κB; NO Synthase; NOD-like Receptor (NLR) ; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mr2938.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OC)=C2C(NC(C3=CC=C(C=C3)N4CCN(CC4)C)=NC2=C1)=O
Molecular Formula
C21H24N4O3
Molecular Weight
380.44
References & Citations
[1]Lv L, et al. Discovery of quinazolin-4 (3H) -one derivatives as novel AChE inhibitors with anti-inflammatory activities. Eur J Med Chem. 2023 Apr 6;254:115346.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; IL-1; IL-6; JNK; NF-κB; NLRP3

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