BPA-B9

• Description :

  BPA-B9 is a RXRα ligand and antagonist targeting the pRXRα-PLK1 interaction. BPA-B9 has excellent RXRα-binding affinity (KD=39.29 ± 1.12 nM) . BPA-B9 inhibits the proliferation of cancer cells by inducing mitotic arrest and cell apoptosis[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Bcl-2 Family; PARP; RAR/RXR

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bpa-b9.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=NC=CC(C2=CC(N3CCC(CC3)CO)=NC=C2)=C1)/C=C/C4=CC=CC=C4

• Molecular Formula :

  C25H26N4O2

• Molecular Weight :

  414.50

• References & Citations :

  [1]Chen J, et al. Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy. Eur J Med Chem. 2023 Apr 6;254:115341.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Bcl-2; Mcl-1; PARP