BPA-B9

• UNSPSC Description:

  BPA-B9 is a RXRα ligand and antagonist targeting the pRXRα-PLK1 interaction. BPA-B9 has excellent RXRα-binding affinity (KD=39.29 ± 1.12 nM). BPA-B9 inhibits the proliferation of cancer cells by inducing mitotic arrest and cell apoptosis[1].

• Target Antigen:

  Apoptosis; Bcl-2 Family; PARP; RAR/RXR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bpa-b9.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=NC=CC(C2=CC(N3CCC(CC3)CO)=NC=C2)=C1)/C=C/C4=CC=CC=C4

• Molecular Weight:

  414.50

• References & Citations:

  [1]Chen J, et al. Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy. Eur J Med Chem. 2023 Apr 6;254:115341.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported