Rovunaptabin

CAT: 0804-HY-148826-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-148826-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Rovunaptabin (ARC 183) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.

CAS Number

145563-68-4

Product Name Alternative

ARC 183; BC 007

UNSPSC

12352208

Target

Thrombin

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/rovunaptabin.html

Purity

98.96

Solubility

10 mM in H2O

Smiles

DNA,d(G-G-T-T-G-G-T-G-T-G-G-T-T-G-G)

References & Citations

[1]Bompiani KM, Monroe DM, Church FC, Sullenger BA. A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity. J Thromb Haemost. 2012;10 (5) :870-880. |[2]Bonifacio L, Church FC, Jarstfer MB. Effect of locked-nucleic acid on a biologically active g-quadruplex. A structure-activity relationship of the thrombin aptamer. Int J Mol Sci. 2008;9 (3) :422-433.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Oligonucleotides

Clinical Information

No Development Reported

Rovunaptabin

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