CDN-A

CAT: 0804-HY-148420Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-148420Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC) . Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes[1][2][3].
CAS Number
[2586047-09-6]
UNSPSC
12352005
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cdn-a.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1COP4(O)=O)OC[C@@H](O5)[C@@H](CCN)[C@@H](O4)[C@@H]5N6C=NC7=C6N=C(N)NC7=O
Molecular Formula
C22H29N11O12P2
Molecular Weight
701.48
References & Citations
[1]Chen, Zhijian, et al. Antinbody-sting agonist conjugates and their use in immunotherapy. US 2021/0015941 Al. 2021.|[2]Lirussi D, et al. Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway. EBioMedicine. 2017 Aug;22:100-111.|[3]Schaap P. Cyclic di-nucleotide signaling enters the eukaryote domain. IUBMB Life. 2013 Nov;65 (11) :897-903.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-156205-01CdnP-IN-1
HY-P70069-01CDNF, Human (HEK293, His)
HY-P75670CDNF, Mouse (HEK293, His)
HY-P76248CDNF, Human (HEK293, Fc)
HY-P700038AF-01Animal-Free CDNF, Human (His)
HY-P700166AF-01Animal-Free CDNF, Mouse (His)
HY-RS24421Cdnf Rat Pre-designed siRNA Set A
HY-RS17950Cdnf Mouse Pre-designed siRNA Set A
HY-RS02420CDNF Human Pre-designed siRNA Set A

Alternative Products

CatalogName
MF-0154901-01CDN-A
561360CDN-1163
MF-0119479-01CDN prodrug-1
5869/50CDN 1163 50 mg
5869/10CDN 1163 10 mg
MBS5823521Mal-VC-PAB-PNP-CDN-A
MBS6464880-01BAK (Apoptosis Regulator Bak, BCL2-antagonist/killer 1, BAK 1, BAK1, BAK-like, Bak NT, Bcl 2-like 7 Protein, BCL2L7, Cell Death Inhibitor 1, CDN 1, CDN1, MGC117255, MGC3887, NBak, Pro Apoptotic Protein BAK) (FITC)
B0055-01PBAK (Apoptosis Regulator Bak, BCL2-antagonist/killer 1, BAK 1, BAK1, BAK-like, Bak NT, Bcl 2-like 7 Protein, BCL2L7, Cell Death Inhibitor 1, CDN 1, CDN1, MGC117255, MGC3887, NBak, Pro Apoptotic Protein BAK) discontinued
MBS6464887-01BAK (Apoptosis Regulator Bak, BCL2-antagonist/killer 1, BAK 1, BAK1, BAK-like, Bak NT, Bcl 2-like 7 Protein, BCL2L7, Cell Death Inhibitor 1, CDN 1, CDN1, MGC117255, MGC3887, NBak, Pro Apoptotic Protein BAK) (PE)
B0055-01Q-APCBAK (Apoptosis Regulator Bak, BCL2-antagonist/killer 1, BAK 1, BAK1, BAK-like, Bak NT, Bcl 2-like 7 Protein, BCL2L7, Cell Death Inhibitor 1, CDN 1, CDN1, MGC117255, MGC3887, NBak, Pro Apoptotic Protein BAK) (APC) discontinued

Popular Products