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Monarsen

CAT: 0804-HY-148412Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-148412Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR) .
CAS Number
864021-55-6
Product Name Alternative
EN101; ODN 7040; BL 7040
UNSPSC
12352208
Target
Cholinesterase (ChE)
Type
Oligonucleotides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/monarsen.html
Solubility
10 mM in DMSO
Smiles
[Monarsen]
References & Citations
[1]Sussman JD, Argov Z, McKee D, Hazum E, Brawer S, Soreq H. Antisense treatment for myasthenia gravis: experience with monarsen. Ann N Y Acad Sci. 2008;1132:283-290. |[2]Evron T, Moyal-Segal LB, Lamm N, Geffen A, Soreq H. RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons. Neurodegener Dis. 2005;2 (1) :16-27. |[3]Kehat R, Zemel E, Cuenca N, et al. A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress. Invest Ophthalmol Vis Sci. 2007;48 (3) :1290-1297.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Isoform
AChE

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