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Macimorelin

CAT: 0804-HY-14820Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14820Size:1 Each
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Description
Macimorelin (EP-1572), a GH secretagogue, is an orally active GHSR agonist. Macimorelin stimulates GH release. Macimorelin can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS) [1][2][3].
CAS Number
381231-18-1
Product Name Alternative
EP-1572; AEZS-130
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
GHSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/macimorelin.html
Solubility
10 mM in DMSO
Smiles
O=CN[C@@H](CC1=CNC2=CC=CC=C12)NC([C@H](NC(C(C)(N)C)=O)CC3=CNC4=CC=CC=C34)=O
Molecular Formula
C26H30N6O3
Molecular Weight
474.55
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Jose M Garcia, et al. Macimorelin as a Diagnostic Test for Adult GH Deficiency. J Clin Endocrinol Metab. 2018 Aug 1;103 (8) :3083-3093. |[2]An Buckinx, et al. Translational potential of the ghrelin receptor agonist macimorelin for seizure suppression in pharmacoresistant epilepsy. Eur J Neurol. 2021 Sep;28 (9) :3100-3112. |[3]Ali SA, Garcia JM. Randomized clinical trial of the novel oral ghrelin mimetic macimorelin in the treatment of cancer cachexia: study design and preliminary results. Endocr Rev. 2013;34:
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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