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Aβ-IN-5

CAT: 0804-HY-147980Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147980Size:1 Each
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Description
Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity[1].
CAS Number
2417977-65-0
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aβ-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C1C)CCC2=C1NC3=C2C=CC=C3)/C=C/C4=CC=C(O)C(O)=C4
Molecular Formula
C21H20N2O3
Molecular Weight
348.40
References & Citations
[1]Liao Q, et al. Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer's disease. Bioorg Chem. 2020 Jun;99:103844.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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