Aβ-IN-5

Aβ-IN-5

• CAS Number: 2417977-65-0
• UNSPSC Description: Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity[1].
• Target Antigen: Amyloid-β; Cholinesterase (ChE)
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/aβ-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N(C1C)CCC2=C1NC3=C2C=CC=C3)/C=C/C4=CC=C(O)C(O)=C4
• Molecular Weight: 348.40
• References & Citations: [1]Liao Q, et al. Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer's disease. Bioorg Chem. 2020 Jun;99:103844.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported