Benz-AP

CAT: 0804-HY-147915Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147915Size:1 Each
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Description
Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids[1].
CAS Number
[2416220-53-4]
UNSPSC
12352005
Target
Carboxylesterase (CES) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/benz-ap.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C2C=CC=C3C(C=CC(C=C1)=C32)=O)C4=CC=CC=C4
Molecular Formula
C20H13NO2
Molecular Weight
299.32
References & Citations
[1]Kailass K, et al. Two-Photon Photodynamic Therapy Targeting Cancers with Low Carboxylesterase 2 Activity Guided by Ratiometric Fluorescence. J Med Chem. 2022 Jun 14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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