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HCAXII-IN-2

CAT: 0804-HY-147829Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147829Size:1 Each
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Description
HCAXII-IN-2 (compound 5i) is a potent human carbonic anhydrase XII (hCA XII) and hCA IX inhibitor with Ki values of 84.2 nM and 268.5 nM, respectively. hCAXII-IN-2 shows less active against hCA I and hCA II[1].
CAS Number
2497504-86-4
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaxii-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(CCl)C2=CC=C(OCC3=CN(CC4=CC=C(OC)C=C4)N=N3)C=C2O1
Molecular Formula
C21H18ClN3O4
Molecular Weight
411.84
References & Citations
[1]Pavitra S Thacker, et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA IX; CA XII

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