JAK3/BTK-IN-6

• UNSPSC Description:

  JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research[1].

• Target Antigen:

  Btk; JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/jak3-btk-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C=CC(NC1=CC(NC2=C(C=NC(NC3=CC=C4B(OCC4=C3)O)=N2)C(F)(F)F)=CC=C1)=O

• Molecular Weight:

  455.20

• References & Citations:

  [1]Ren J, et al. Design and synthesis of boron-containing diphenylpyrimidines as potent BTK and JAK3 dual inhibitors. Bioorg Med Chem. 2020 Jan 15;28(2):115236.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2243136-03-8