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Taragarestrant

CAT: 0804-HY-147402Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147402Size:1 Each
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Description
Taragarestrant (D-0502) is a potent, orally active and selective estrogen receptor degrader (SERD) . Taragarestrant shows potent activity in various ER+ breast cancer cell lines and xenograft models[1][2].
CAS Number
2118899-51-5
Product Name Alternative
D-0502
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/taragarestrant.html
Solubility
10 mM in DMSO
Smiles
CC(C)(F)CN1[C@@](C2=C(C=C(C=C2Cl)/C=C/C(O)=O)Cl)([H])C3=C(C[C@H]1C)C4=CC=CC=C4N3
Molecular Formula
C25H25Cl2FN2O2
Molecular Weight
475.38
References & Citations
[1]Lin WY, et, al. Abstract 5776: Pharmacologic and PK/PD study of D-0502: An orally bioavailable SERD with potent antitumor activity in ER-positive breast cancer cell lines and xenograft models. 2018 Jul 1;78 (13) :5776.|[2]WHO Drug Information. International Nonproprietary Names for Pharmaceutical
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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