Products for Research Use Only
RegisterLogin

YL93

CAT: 0804-HY-146806Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-146806Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. YL93 induces cell-cycle arrest and apoptosis. YL93 shows p53-dependent cell growth inhibition[1].
CAS Number
2771313-42-7
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yl93.html
Solubility
10 mM in DMSO
Smiles
FC(C(Cl)=CC=C1)=C1[C@@H]([C@@H](N[C@H]2CC(C)(C)C)C(NC3=CC=C(C=C3OC)C(O)=O)=O)[C@]2(C4=CC=C(Cl)C=C4F)CNCC5=CC=NC=C5
Molecular Formula
C37H38Cl2F2N4O4
Molecular Weight
711.62
References & Citations
[1]Zhang S, et al. Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells. J Med Chem. 2022 Apr 28;65 (8) :6207-6230.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Popular Products