5-HT6R/MAO-B modulator 1

• UNSPSC Description:

  5-HT6R/MAO-B modulator 1 (compound 48) is an antagonist of 5-HT6R at Gs signaling and an irreversible MAO-B inhibitor. 5-HT6R/MAO-B modulator 1 exhibits glioprotective properties. 5-HT6R/MAO-B modulator 1 can reverse Scopolamine-induced memory deficits[1]. 5-HT6R/MAO-B modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  5-HT Receptor; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/5-ht6r-mao-b-modulator-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(CC#C)CC1=CC=C(C=C1)OCCCCCN2CCN(CC2)C3=C4C=CN(C4=CC=C3)S(=O)(C5=CC=CC=C5)=O

• Molecular Weight:

  584.77

• References & Citations:

  [1]Canale V, et, al. A dual-acting 5-HT 6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties. Eur J Med Chem. 2020 Dec 15;208:112765.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2986222-45-9