Dexamethasone-d3-1

Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

Hexadecadrol-d3-1; Prednisolone F-d3-1

12352211

H302, H315, H319, H335

ADC Payload; Antibiotic; Autophagy; Bacterial; Complement System; Glucocorticoid Receptor; Isotope-Labeled Compounds; Mitophagy; SARS-CoV

Isotope-Labeled Compounds

Antibody-drug Conjugate/ADC Related; Anti-infection; Autophagy; Immunology/Inflammation; Others; Vitamin D Related/Nuclear Receptor

Cancer-programmed cell death

Cancer

98.02

10 mM in DMSO

OCC([C@@]1([C@@]2([C@]([C@]3([C@@]([C@]4(C=CC(C=C4CC3)=O)C)([C@H](C2)O)F)[H])(C[C@H]1C([2H])([2H])[2H])[H])C)O)=O

C22H26D3FO5

395.48

H302, H315, H319, H335

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122 (2) :249-56|[3]Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541 (1-3) :75-9.|[4]LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31 (3) :611-22.|[5]Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127 (4) :1003-11|[6]Ballabh P, et al. Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids. Arch Dis Child Fetal Neonatal Ed. 2004 Jan;89 (1) :F76-83.|[7]Heidi Ledford. et al. Coronavirus Breakthrough: Dexamethasone Is First Drug Shown to Save Lives. Nature. 2020 Jun 16.|[8]Yun Chen, et al. Glucocorticoids inhibit production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Int J Clin Exp Pathol 2018;11 (7) :3391-3397.

Blue Ice

-20°C (Powder, protect from light, stored under nitrogen)

Isotope-Labeled Compounds