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HF50731

CAT: 0804-HY-146413Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146413Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HF50731 (compound 21) is a potent CXCR4 antagonist. HF50731 shows strong CXCR4 binding affinity, with IC50 of 19.8 nM. HF50731 effectively inhibits calcium mobilization, cell migration, and HIV-1 infection via CXCR4 coreceptor, with IC50 values of 119.2 nM, 621.4 nM and 1.5 μM[1].
CAS Number
2484771-19-7
UNSPSC
12352005
Target
CXCR; HIV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/hf50731.html
Solubility
10 mM in DMSO
Smiles
C1(CNCCCNC2CCCCC2)=CC=C(CNCCCNC3CCCCC3)C=C1
Molecular Formula
C26H46N4
Molecular Weight
414.67
References & Citations
[1]Fang X, Meng Q, Zhang H, Liang B, Zhu S, Wang J, Zhang C, Huang LS, Zhang X, Schooley RT, An J, Xu Y, Huang Z. Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists. Eur J Med Chem. 2020 Aug 15;200:112410.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR4; HIV-1

Alternative Products

CatalogName
T62140-01HF50731

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