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S1427

CAT: 0804-HY-146380Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146380Size:1 Each
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Description
S1427 is a tranylcypromine-derived LSD1 inhibitor with the IC50 of 390 nM and Ki of 80 nM. S1427 exhibits desirable hERG channel inhibition and microsomal stability profiles. Inhibition of LSD1 partially reduces the proliferation of cancer cells[1].
CAS Number
2447061-40-5
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s1427.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC2(CC1)CCNC2)CN[C@H]3C[C@@H]3C4=C(C(F)=CC(F)=C4)OCC5=CC=CN=C5F
Molecular Formula
C25H29F3N4O2
Molecular Weight
474.52
References & Citations
[1]Yasuko Koda, et al. Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. ACS Med Chem Lett. 2022 Apr 29;13 (5) :848-854.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

Alternative Products

CatalogName
T63085-01S1427

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