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Collagen-IN-1

CAT: 0804-HY-146332Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146332Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC50 value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research[1].
CAS Number
104260-73-3
UNSPSC
12352005
Target
P-selectin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/collagen-in-1.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=C2[C@@]3(CCCC3)C=CC4=O[H]OC1=C42
Molecular Formula
C14H14O3
Molecular Weight
230.26
References & Citations
[1]Diego Méndez, et al. Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6. Eur J Med Chem. 2020 Apr 15;192:112187.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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