LDC0496

CAT: 0804-HY-146262Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-146262Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome[1].

CAS Number

2411874-83-2

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ldc0496.html

Solubility

10 mM in DMSO

Smiles

CC(C=CC(C1=C(NC2=NC=C(C=C21)C(OC(C)C)=O)C3=CC=C(C=C3)N4CCN(CC4)C)=C5)=C5NC(C=C)=O

Molecular Formula

C32H35N5O3

Molecular Weight

537.65

References & Citations

[1]Lategahn J, et al. Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. J Med Chem. 2022;65 (9) :6643-6655.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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GTR19184826-01	LDC0496

LDC0496

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