Aβ-IN-4

Aβ-IN-4

• CAS Number: 2477606-97-4
• UNSPSC Description: Aβ-IN-4 (compound 12) is a potent amyloid β (Aβ) inhibitor. Aβ-IN-4 inhibits Aβ42 aggregation. However, Aβ-IN-4 can not alleviate the neurotoxicity of Aβ42 in SH-SY5Y cells. Aβ-IN-4 can not change the aggregation state of Aβ42 into a nontoxic one[1].
• Target Antigen: Amyloid-β
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/aβ-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H](CC1=CC=C(OC/C=C/C[C@@H](C(N2)=O)NC([C@@H](N)CC(C)C)=O)C=C1)C(N[C@@H](C)C(O)=O)=O)[C@@H]2CC3=CC=CC=C3
• Molecular Weight: 621.72
• References & Citations: [1]Tanaka F, et al. Design and synthesis of β-strand-fixed peptides inhibiting aggregation of amyloid β-protein. Bioorg Med Chem. 2020 Sep 15;28(18):115676.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported