Grb2 SH2 domain inhibitor 1

• UNSPSC Description:

  Grb2 SH2 domain inhibitor 1 is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

• Target Antigen:

  EGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/grb2-sh2-domain-inhibitor-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC([C@@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H]3CCCN3C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC(N)=O)=O)CC4=CC=CC=C4)=O)CC5=CC=C6C=CC=CC6=C5)=O)CCCNC(N)=N)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC7=CC=C(C=C7)OP(O)(O)=O)=O)C

• Molecular Weight:

  1463.58

• References & Citations:

  [1]Wen J,et al. Rational design of cell-permeable cyclic peptides containing a d-Pro-l-Pro motif. Bioorg Med Chem. 2020 Oct 15;28(20):115711.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported