Grb2 SH2 domain inhibitor 1

Grb2 SH2 domain inhibitor 1

• UNSPSC Description: Grb2 SH2 domain inhibitor 1 is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.
• Target Antigen: EGFR
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/grb2-sh2-domain-inhibitor-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC([C@@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H]3CCCN3C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC(N)=O)=O)CC4=CC=CC=C4)=O)CC5=CC=C6C=CC=CC6=C5)=O)CCCNC(N)=N)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC7=CC=C(C=C7)OP(O)(O)=O)=O)C
• Molecular Weight: 1463.58
• References & Citations: [1]Wen J,et al. Rational design of cell-permeable cyclic peptides containing a d-Pro-l-Pro motif. Bioorg Med Chem. 2020 Oct 15;28(20):115711.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported