HP1328

CAT: 0804-HY-145690Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-145690Size:1 Each

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Description

HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation) . HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia[1].

CAS Number

2245074-20-6

UNSPSC

12352005

Target

FLT3

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hp1328.html

Solubility

10 mM in DMSO

Smiles

OCCOC1=CC=C(CNC2=CC(N=CN3C4=CC=CC=C4)=C3C=C2)C=C1OC

Molecular Formula

C23H23N3O3

Molecular Weight

389.45

References & Citations

[1]Tian T, et al. Identification of the Benzoimidazole Compound as a Selective FLT3 Inhibitor by Cell-Based High-Throughput Screening of a Diversity Library. J Med Chem. 2022 Feb 24;65 (4) :3597-3605.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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