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NU5455

CAT: 0804-HY-145427-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145427-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NU5455 is a potent, selective, and orally active inhibitor of DNA-PKcs. NU5455 administration increases both the efficacy and the toxicity of a parenterally administered topoisomerase inhibitor. NU5455 enhances the activity of Doxorubicin released locally in liver tumor xenografts without inducing any adverse effect[1].
CAS Number
1257235-99-6
UNSPSC
12352005
Target
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nu5455.html
Solubility
10 mM in DMSO
Smiles
CN(C1=CC=C2SC3=C(C4=C(OC(N5CC(CC6)OC6C5)=CC7=O)C7=CC=C4)C=CC=C3C2=C1)C(CN8CCOCC8)=O
Molecular Formula
C34H33N3O5S
Molecular Weight
595.71
References & Citations
[1]Willoughby CE, et al. Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy. J Clin Invest. 2020;130 (1) :258-271.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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