IRE1α kinase-IN-4

• UNSPSC Description:

  IRE1α kinase-IN-4 (compound 6) is a potent IRE1α inhibitor with an Ki of 140 nM. IRE1α kinase-IN-4 is the ATP-competitive ligands of IRE1α[1].

• Target Antigen:

  IRE1

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ire1α-kinase-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1CC1)NC(C2=C3C=CC=C2)=CC=C3OC4=NC=CC=C4C5=NC(N[C@H]6CC[C@H](N)CC6)=NC=C5

• Molecular Weight:

  509.60

• References & Citations:

  [1]Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021 Nov;17(11):1148-1156.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2771006-45-0