Vanin-1-IN-2

• Description :

  Vanin-1-IN-2 is a potent vanin-1 inhibitor with an IC50 of 162 nM. Vanin-1 is a cell-surface-associated, glycosylphosphatidyl inositol (GPI) -anchored protein which is expressed at high levels in the kidney, liver, and small intestine[1].

• UNSPSC :

  12352005

• Target :

  Pantetheinase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/vanin-1-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CN=C(NCC2=CC=CN=C2)N=C1)C3=CC=CS3

• Molecular Formula :

  C15H12N4OS

• Molecular Weight :

  296.35

• References & Citations :

  [1]Casimiro-Garcia A, et al. Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem. 2022;65 (1) :757-784.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2054952-13-3]