Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH

Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH

• CAS Number: 1637413-46-7
• UNSPSC Description: Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].
• Target Antigen: PROTAC Linkers; Toll-like Receptor (TLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PROTAC
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/tri-tlr4-in-c34-c2-amide-c3-amide-peg1-amide-c3-cooh.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(O)CCCC(NC(COCCC(NCCCNC(CCCCO[C@H]1[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O1)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]2[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O2)=O)=O)COCCC(NCCCNC(CCCCO[C@H]3[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O3)=O)=O)=O
• Molecular Weight: 1908.01
• References & Citations: [1]Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779. Published 2013 Jun 12.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported