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PNU-EDA-Gly5

CAT: 0804-HY-145078Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145078Size:1 Each
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Description
PNU-EDA-Gly5 is an oligo-glycine linker-payload for ADC synthesis, composed of a DNA topoisomerase I inhibitor PNU-159682 and a linker EDA-Gly5[1].
CAS Number
1957223-28-7
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pnu-eda-gly5.html
Solubility
10 mM in DMSO
Smiles
OC1=C2C(C(C3=C(OC)C=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@]6([H])N7[C@]([C@H](OCC7)OC)([H])O[C@]6([H])[C@@H](O5)C)=C1C[C@](O)(C4)C(NCCNC(CNC(CNC(CNC(CNC(CN)=O)=O)=O)=O)=O)=O
Molecular Formula
C43H54N8O17
Molecular Weight
954.93
References & Citations
[1]Quintieri L, et al. Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes. Clin Cancer Res. 2005 Feb 15;11 (4) :1608-17.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported

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