EGFR-IN-3

• UNSPSC Description:

  EGFR-IN-3 (Compound 4c) is a potent EGFR inhibitor with an IC50 of 0.32 µM against EGFRwt-TK. EGFR-IN-3 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].

• Target Antigen:

  Apoptosis; EGFR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/egfr-in-3-11.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C(NC2=NC(NC3=CC=C(NC(C4=CC=CC(F)=C4)=O)C=C3)=NC=C2C(F)(F)F)SC=C1)NC

• Molecular Weight:

  530.50

• References & Citations:

  [1]Yan L, et al. Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):832-843.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3031812-65-1