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GAT564

CAT: 0804-HY-144705Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144705Size:1 Each
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Description
GAT564 (Compound 15d) is a potent allosteric modulator of cannabinoid 1 receptor (CB1R) with EC50s of 87 and 320 nM respectively for cAMP and β-arrestin2. GAT564 markedly promotes orthosteric ligand binding to hCB1R. GAT564 is efficacious as a topical agent that significantly reduces intraocular pressure (IOP) in the ocular normotensive murine model of glaucoma[1].
CAS Number
2851895-01-5
UNSPSC
12352005
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gat564.html
Solubility
10 mM in DMSO
Smiles
O=[N+](CC(C1=C(NC2=CC=CC=C21)C3=CSC=C3)C4=CC=CC=C4)[O-]
Molecular Formula
C20H16N2O2S
Molecular Weight
348.42
References & Citations
[1]Garai S, et al. Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure. Bioorg Med Chem. 2021;50:116421.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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